Management

Dr. Crooke is Founder, Chairman and Chief Executive Officer of Isis Pharmaceuticals. Since Dr. Crooke and his colleagues founded Isis in 1989, the Company completed its initial public offering in May 1991, and has reported broad progress in antisense technology and its rapid conversion to therapeutic product opportunities. Isis was the first company to commercialize an antisense drug and has achieved a number of important corporate collaborative relationships. In 2006, Dr. Crooke was named in Nature Biotechnology as one of biotechnology’s influential individuals.

Dr. Crooke is currently on the Board of Regulus Therapeutics Inc., a company jointly owned by Isis. Dr. Crooke is currently a member of the Current Drugs Advisory Board, and the Editorial Board of Gene Therapy and Molecular Biology. He is also Editor-in-Chief of Current Opinion in Anticancer Drugs and Section Editor for Biologicals and Immunologicals for Expert Opinion on Investigational Drugs.

Prior to founding Isis, Dr. Crooke was President of Research and Development for SmithKline Beckman Corporation (SKB). He also coordinated the research and development activities of SKB including its instruments, diagnostics, animal health and clinical laboratory businesses.

Prior to joining SKB, Dr. Crooke helped establish the anticancer drug discovery and development program at Bristol Myers, which succeeded in bringing to market a significant number of drugs.

During his career, Dr. Crooke has supervised the development of 19 drugs currently on the market and others in development. In addition to his involvement in the pharmaceutical industry, Dr. Crooke also maintains active academic positions. He is an adjunct professor at San Diego State University, and has won a number of teaching awards. He has authored over 400 publications and has edited 20 books. Dr. Crooke is active in molecular and cellular biology and pharmacology of antisense oligonucleotides.

Dr. Crooke received his M.D. and Ph.D. from Baylor College of Medicine, Houston, Texas and his B.S. in Pharmacy from Butler University, Indianapolis, Indiana.

Ms. Parshall is Director, Chief Operating Officer and Chief Financial Officer of Isis Pharmaceuticals. She is responsible for overseeing the operations of finance, legal, patents, manufacturing, and business development and is also very involved in the Company’s corporate communications activities. Ms. Parshall joined Isis in November 1991.

Previously, Ms. Parshall was a Partner with the firm of Cooley Godward LLP, now Cooley Godward Kronish LLP, where she represented several health care companies in a general practice specializing in corporate partnering and other technology-based transactions.

Ms. Parshall received her J.D. at Stanford Law School, Stanford, California and her B.A. from Harvard University, Cambridge, Massachusetts. Ms. Parshall is currently on the Board of Regulus Therapeutics Inc., a company jointly owned by Isis. Ms. Parshall is also a member of the Licensing Executives Society and a member of the American, California, and San Diego bar associations.

Dr. Bennett is Senior Vice President of Research at Isis Pharmaceuticals. He is responsible for preclinical antisense drug discovery and antisense technology research. Dr. Bennett is one of the founding members of the Company. He has been involved in the development of antisense oligonucleotides as therapeutic agents, including research on the application of oligonucleotides for inflammatory, neurodegenerative diseases and cancer targets, oligonucleotide delivery and pharmacokinetics. He also runs the Company's antisense mechanism program which is focused on the development of RNase H, RNAi, micro-RNA and splicing. Dr. Bennett has published more than 130 papers in the field of antisense research and development and has more than 120 issued U.S. patents.

Prior to joining Isis, Dr. Bennett was Associate Senior Investigator in the Department of Molecular Pharmacology at SmithKline and French Laboratories, GlaxoSmithKline (currently, GlaxoSmithKline).

Dr. Bennett received his Ph.D. in Pharmacology from Baylor College of Medicine, Houston, Texas and his B.S. degree in Pharmacy from the University of New Mexico, Albuquerque, New Mexico. Dr. Bennett performed his postdoctoral research in the Department of Molecular Pharmacology at SmithKline and French Laboratories, where he studied the signal transduction pathway of leukotrienes. Dr. Bennett serves on the Board of Directors of Altair Therapeutics, Inc., the Scientific Advisory Board for the Keystone Symposia, and the Advisory Board for the Experimental Therapeutics Centre in Singapore.

Dr. Geary is Senior Vice President of Development at Isis Pharmaceuticals. He is responsible for preclinical and clinical development of antisense drugs. Since joining Isis in 1995, Dr. Geary has been involved in discovery and development including the regulatory submission of more than 10 investigational new drug applications to U.S. and other regulatory agencies. During his tenure at Isis, he has authored or coauthored 10 book chapters and more than 40 peer-reviewed manuscripts, which form a body of work that fully characterize the pharmacokinetics and metabolism of antisense drugs and the relationship of drug concentrations to activity and safety.

Prior to joining Isis, Dr. Geary was Senior Research Scientist and Group Leader for the bioanalytical and preclinical pharmacokinetics group in the Applied Chemistry Department at Southwest Research Institute. Dr. Geary received his Ph.D. in Biopharmaceutics from the University of Texas, College of Pharmacy, Austin, Texas and his B.S. in Biology from Texas A&M University, College Station, Texas.