New Articles

Nuclear Envelope Phosphatase 1-Regulatory Subunit 1 (Formerly TMEM188) Is the Metazoan Spo7p Ortholog and Functions in the Lipin Activation Pathway

Han S, Bahmanyar S, Zhang P, Grishin N, Oegema K, Crooke R, Graham M, Reue K, Dixon JE, Goodman JM

J Biol Chem. 2012 Jan 27;287(5):3123-37

Structural Requirements for Hybridization at the 5'-Position are Different in α-l-LNA as Compared to β-d-LNA

Seth PP, Allerson CR, Ostergaard ME, Swayze EE

Bioorg Med Chem Lett. 2012 Jan 1;22(1):296-9

Antisense Inhibition of Coagulation Factor XI Prolongs APTT Without Increased Bleeding Risk in Cynomolgus Monkeys

Younis HS, Crosby J, Huh JI, Lee HS, Rime S, Monia B, Henry SP

Blood. 2012 Jan 13. [Epub ahead of print]

Endothelial Lipase Mediates HDL Levels in Normal and Hyperlipidemic Rabbits

Zhang J, Yu Y, Nakamura K, Koike T, Waqar AB, Zhang X, Liu E, Nishijima K, Kitajima S, Shiomi M, Qi Z, Yu J, Graham MJ, Crooke RM, Ishida T, Hirata KI, Hurt-Camejo E, Chen YE, Fan J

J Atheroscler Thromb. 2012 Jan 12. [Epub ahead of print]

Inhibition of Hepatic Sulf2 in vivo: A Novel Strategy to Correct Diabetic Dyslipidemia

Hassing HC, Mooij H, Guo S, Monia BP, Chen K, Kulik W, Dallinga-Thie GM, Nieuwdorp M, Stroes ES, Williams KJ

Hepatology. 2012 Jan 11. doi: 10.1002/hep.25580. [Epub ahead of print]

Insights from Crystal Structures Into the Opposite Effects on RNA Affinity Caused by the s- and R-6'-Methyl Backbone Modifications of 3'-Fluoro Hexitol Nucleic Acid

Pallan PS, Yu J, Allerson CR, Swayze EE, Seth P, Egli M

Biochemistry. 2012 Jan 10;51(1):7-9

CGI-58/ABHD5-Derived Signaling Lipids Regulate Systemic Inflammation and Insulin Action

Lord CC, Betters JL, Ivanova PT, Milne SB, Myers DS, Madenspacher J, Thomas G, Chung S, Liu M, Davis MA, Lee RG, Crooke RM, Graham MJ, Parks JS, Brasaemle DL, Fessler MB, Brown HA, Brown JM

Diabetes. 2012 Jan 6. [Epub ahead of print]

Antisense Reduction of 11β-Hydroxysteroid Dehydrogenase Type 1 Enhances Energy Expenditure and Insulin Sensitivity iIdependent of Food Intake in C57BL/6J Mice on a Western-Type Diet

Li G, Hernandez-Ono A, Crooke RM, Graham MJ, Ginsberg HN

Metabolism. 2011 Dec 28. [Epub ahead of print]

Potent and Selective Antisense Oligonucleotides Targeting Single-Nucleotide Polymorphisms in the Huntington Disease Gene / Allele-Specific Silencing of Mutant Huntingtin

Carroll JB, Warby SC, Southwell AL, Doty CN, Greenlee S, Skotte N, Hung G, Bennett CF, Freier SM, Hayden MR

Mol Ther. 2011 Dec;19(12):2178-85. doi: 10.1038/mt.2011.201

Selective Depletion of Plasma Prekallikrein or Coagulation Factor XII Inhibits Thrombosis in Mice Without Increased Risk of Bleeding

Revenko AS, Gao D, Crosby JR, Bhattacharjee G, Zhao C, May C, Gailani D, Monia BP, Macleod AR

Blood. 2011 Nov 10;118(19):5302-11

Efficacy of Apolipoprotein B Synthesis Inhibition in Subjects With Mild-to-Moderate Hyperlipidaemia

Akdim F, Tribble DL, Flaim JD, Yu R, Su J, Geary RS, Baker BF, Fuhr R, Wedel MK, Kastelein JJ

Eur Heart J. 2011 Nov;32(21):2650-9

Synthesis, Improved Antisense Activity and Structural Rationale for the Divergent RNA Affinities of 3'-Fluoro Hexitol Nucleic Acid (FHNA and Ara-FHNA) Modified Oligonucleotides

Egli M, Pallan PS, Allerson CR, Prakash TP, Berdeja A, Yu J, Lee S, Watt AT, Gaus H, Bhat B, Swayze EE, Seth PP

J Am Chem Soc. 2011 Oct 19;133(41):16642-9

A Phase 1 Dose Escalation, Pharmacokinetic, and Pharmacodynamic Evaluation of eIF-4E Antisense Oligonucleotide LY2275796 in Patients With Advanced Cancer

Hong DS, Kurzrock R, Oh Y, Wheler J, Naing A, Brail L, Callies S, André V, Kadam SK, Nasir A, Holzer TR, Meric-Bernstam F, Fishman M, Simon G

Clin Cancer Res. 2011 Oct 15;17(20):6582-91

Peripheral SMN Restoration is Essential for Long-Term Rescue of a Severe Spinal Muscular Atrophy Mouse Model

Hua Y, Sahashi K, Rigo F, Hung G, Horev G, Bennett CF, Krainer AR

Nature. 2011 Oct 5;478(7367):123-6. doi: 10.1038/nature10485.

Antisense Oligonucleotide Suppression of Serum Amyloid A Reduces Amyloid Deposition in Mice with AA Amyloidosis

Kluve-Beckerman B, Hardwick J, Du L, Benson MD, Monia BP, Watt A, Crooke RM, Mullick A

Amyloid. 2011 Sep;18(3):136-46

Thrombomodulin is a Determinant of Metastasis Through a Mechanism Linked to the Thrombin Binding Domain but not the Lectin-like Domain

Horowitz NA, Blevins EA, Miller WM, Perry AR, Talmage KE, Mullins ES, Flick MJ, Queiroz KC, Shi K, Spek CA, Conway EM, Monia BP, Weiler H, Degen JL, Palumbo JS

Blood. 2011 Sep 8;118(10):2889-95

An Overview of Sugar-Modified Oligonucleotides for Antisense Therapeutics

Prakash TP

Chem Biodivers. 2011 Sep;8(9):1616-41. doi: 10.1002/cbdv.201100081

Synthesis and Biophysical Evaluation of 3'-Me-α-l-LNA - Substitution in the Minor Groove of α-l-LNA Duplexes

Seth PP, Allerson CA, Ostergaard ME, Swayze EE

Bioorg Med Chem Lett. 2011 Aug 15;21(16):4690-4

Lowering Apolipoprotein CIII Delays Onset of Type 1 Diabetes

Holmberg R, Refai E, Höög A, Crooke RM, Graham M, Olivecrona G, Berggren P and Juntti-Berggren L

Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10685-9

Mechanisms of Single-Stranded Phosphorothioate Modified Antisense Oligonucleotide Accumulation in Hepatocytes

Koller E, Vincent TM, Chappell A, De S, Manoharan M, Bennett CF

Nucleic Acids Res. 2011 Jun;39(11):4795-807

Depletion of Key Protein Components of the RISC Pathway Impairs Pre-Ribosomal RNA Processing

Liang XH, Crooke ST

Nucleic Acids Res. 2011 Jun;39(11):4875-89

Antisense Oligonucleotide Reduction of apoB Ameliorated Atherosclerosis in LDL Receptor-Deficient Mice

Mullick AE, Fu W, Graham MJ, Lee RG, Witchell D, Bell TA, Whipple CP, Crooke RM

J Lipid Res. 2011 May;52(5):885-96

U1 Adaptors Result in Reduction of Multiple Pre-mRNA Species Principally by Sequestering U1snRNP

Vickers TA, Sabripour M, Crooke ST

Nucleic Acids Res. 2011 May;39(10):e71

Effects of Antisense-Mediated Inhibition of 11β-hydroxysteroid Dehydrogenase Type 1 on Hepatic Lipid Metabolism

Li G, Hernandez-Ono A, Crooke RM, Graham MJ, Ginsberg HN

J Lipid Res. 2011 May;52(5):971-81

Antisense Oligonucleotide Lowers Plasma Levels of Apolipoprotein (a) and Lipoprotein (a) in Transgenic Mice

Merki E, Graham M, Taleb A, Leibundgut G, Yang X, Miller ER, Fu W, Mullick AE, Lee R, Willeit P, Crooke RM, Witztum JL, Tsimikas S

J Am Coll Cardiol. 2011 Apr 12;57(15):1611-21

Long pre-mRNA Depletion and RNA Missplicing Contribute to Neuronal Vulnerability from Loss of TDP-43

Polymenidou M, Lagier-Tourenne C, Hutt KR, Huelga SC, Moran J, Liang TY, Ling SC, Sun E, Wancewicz E, Mazur C, Kordasiewicz H, Sedaghat Y, Donohue JP, Shiue L, Bennett CF, Yeo GW, Cleveland DW

Nat Neurosci. 2011 Apr;14(4):459-68

Allele-selective Inhibition of Ataxin-3 (ATX3) Expression by Antisense Oligomers and Duplex RNAs

Hu J, Gagnon KT, Liu J, Watts JK, Syeda-Nawaz J, Bennett CF, Swayze EE, Randolph J, Chattopadhyaya J, Corey DR

Biol Chem. 2011 Apr;392(4):315-25

Antisense Oligonucleotides Delivered to the Mouse CNS Ameliorate Symptoms of Severe Spinal Muscular Atrophy

Passini MA, Bu J, Richards AM, Kinnecom C, Sardi SP, Stanek LM, Hua Y, Rigo F, Matson J, Hung G, Kaye EM, Shihabuddin LS, Krainer AR, Bennett CF, Cheng SH

Sci Transl Med. 2011 Mar 2;3(72):72ra18

Synthesis of 2',4'-bridged Nucleosides Using a New Orthogonally Protected Sugar Synthon: 5-O-(tert-butyldiphenylsilyl)-4-C-hydroxymethyl-1,2-O-isopropylidene-3-O-napthyl-α-D-allofuranose

Seth PP, Prakash TP

Curr Protoc Nucleic Acid Chem. 2011 Mar;Chapter 1:Unit 1.24

Control of RNA Processing by a Large Noncoding RNA Over-expressed in Carcinomas

Lin R, Roychowdhury-Saha M, Black C, Watt AT, Marcusson EG, Freier SM, Edgington TS

FEBS Lett. 2011 Feb 18;585(4):671-6

Efficient and Specific Knockdown of Small Non-Coding RNAs in Mammalian Cells and in Mice

Xue-hai Liang, Timothy A. Vickers, Shuling Guo and Stanley T. Crooke

Nucleic Acids Res. 2011 Feb 1;39(3):e13

Transcription Factor Stat5 Knockdown Enhances Androgen Receptor Degradation and Delays Castration-Resistant Prostate Cancer Progression In vivo

Thomas C, Zoubeidi A, Kuruma H, Fazli L, Lamoureux F, Beraldi E, Monia BP, Macleod AR, Thüroff JW, Gleave ME

Mol Cancer Ther. 2011 Feb;10(2):347-59

Antisense Inhibition of Survivin Expression as a Cancer Therapeutic

Carrasco RA, Stamm NB, Marcusson E, Sandusky G, Iversen P, Patel BK

Mol Cancer Ther. 2011 Feb;10(2):221-32