Cardiovascular

Inhibition of the Intrinsic Coagulation Pathway Factor XI by Antisense Oligonucleotides: a Novel Antithrombotic Strategy With Lowered Bleeding Risk

Zhang H, Löwenberg EC, Crosby JR, Macleod AR, Zhao C, Gao D, Black C, Revenko AS, Meijers JC, Stroes ES, Levi M, Monia BP

Blood. 2010 Nov 25;116(22):4684-92

Coagulation Factor XI as a Novel Target for Antithrombotic Treatment

Löwenberg EC, Meijers JC, Monia BP, Levi M

J Thromb Haemost. 2010 Nov;8(11):2349-57

Decreased Expression of ARV1 Results in Cholesterol Retention in the Endoplasmic Reticulum and Abnormal Bile Acid Metabolism

Tong F, Billheimer J, Shechtman CF, Liu Y, Crooke R, Graham M, Cohen DE, Sturley SL, Rader DJ

J Biol Chem. 2010 Oct 29;285(44):33632-41

Effect of Apolipoprotein-B Synthesis Inhibition on Liver Triglyceride Content in Patients With Familial Hypercholesterolemia

Visser ME, Akdim F, Tribble DL, Nederveen AJ, Kwoh TJ, Kastelein JJ, Trip MD, Stroes ES

J Lipid Res. 2010 May;51(5):877-8

Efficacy and Safety of Mipomersen, an Antisense Inhibitor of Apolipoprotein B, in Hypercholesterolemic Subjects Receiving Stable Statin Therapy

Akdim F, Stroes ES, Sijbrands EJ, Tribble DL, Trip MD, Jukema JW, Flaim JD, Su J, Yu R, Baker BF, Wedel MK, Kastelein JJ

J Am Coll Cardiol. 2010 Apr 13;55(15):1611-8

Mipomersen, an Apolipoprotein B Synthesis Inhibitor, for Lowering of LDL Cholesterol Concentrations in Patients With Homozygous Familial Hypercholesterolaemia: a Randomised, Double-Blind, Placebo-Controlled Trial

Raal FJ, Santos RD, Blom DJ, Marais AD, Charng MJ, Cromwell WC, Lachmann RH, Gaudet D, Tan JL, Chasan-Taber S, Tribble DL, Flaim JD, Crooke ST

Lancet. 2010 Mar 20;375(9719):959-61

Cross-species Comparison of In Vivo PK/PD Relationships for Second Generation Antisense Oligonucleotides Targeting Apolipoprotein B-100.

Yu RZ, Lemonidis KM, Graham MJ, Matson J, Crooke RM, Tribble D, Wedel M, Levin AA, Geary RS.

Biochem Pharmacol. 2009 Mar 1;77(5):910-9. Epub 2008 Nov 14.

Lack of Pharmacokinetic Interaction of Mipomersen Sodium (ISIS 301012), a 2'-O-Methoxyethyl Modified Antisense Oligonucleotide Targeting Apolipoprotein B-100 Messenger RNA, with Simvastatin and Ezetimibe.

Yu RZ, Geary RS, Flaim JD, Riley GC, Tribble DL, vanVliet AA, Wedel MK.

Clinical Pharmacokinetics. 2009 January;48(1):39-50.

Antisense Oligonucleotide Directed to Human Apolipoprotein B-100 Reduces Lipoprotein(a) Levels and Oxidized Phospholipids on Human Apolipoprotein B-100 Particles in Lipoprotein(a) Transgenic Mice.

Merki E, Graham MJ, Mullick AE, Miller ER, Crooke RM, Pitas RE, Witztum JL, Tsimikas S.

Circulation. 2008 August;118:743-753.

Antisense Inhibition of Proprotein Convertase Subtilisin Kexin 9 Reduces Serum LDL in Hyperlipidemic Mice.

Graham MJ, Lemonidis KM, Whipple CP, Subramaniam A, Monia BP, Crooke ST, Crooke RM.

J Lipid Res. 2007 Jan 24

Aberrant Hepatic Expression of PPAR{gamma}2 Stimulates Hepatic Lipogenesis in a Mouse Model of Obesity, Insulin Resistance, Dyslipidemia, and Hepatic Steatosis.

Zhang YL, Hernandez-Ono A, Siri P, Weisberg S, Conlon D, Graham MJ, Crooke RM, Huang LS, Ginsberg HN.

J Biol Chem. 2006 Dec 8;281(49):37603-15

Potent reduction of apolipoprotein B and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein B.

Kastelein JJ, Wedel MK, Baker BF, Su J, Bradley JD, Yu RZ, Chuang E, Graham MJ, Crooke RM.

Circulation. 2006 Oct 17;114(16):1729-35.

Drug evaluation: ISIS-301012, an antisense oligonucleotide for the treatment of hypercholesterolemia.

Burnett JR.

Curr Opin Mol Ther. 2006 Oct;8(5):461-7.

Liver-specific inhibition of acyl-coenzyme a:cholesterol acyltransferase 2 with antisense oligonucleotides limits atherosclerosis development in apolipoprotein B100-only low-density lipoprotein receptor-/- mice.

Bell TA 3rd, Brown JM, Graham MJ, Lemonidis KM, Crooke RM, Rudel LL.

Arterioscler Thromb Vasc Biol. 2006 Aug;26(8):1814-20.

An Apolipoprotein B Antisense Oligonucleotide Lowers LDL Cholesterol in Hyperlipidemic Mice without Causing Hepatic Steatosis.

Crooke RM, Graham MJ, Lemonidis KM, Whipple CP, Koo S, Perera RJ.

J Lipid Res. 2005 May;46(5):872-84