Cardiovascular

Cross-species Comparison of In Vivo PK/PD Relationships for Second Generation Antisense Oligonucleotides Targeting Apolipoprotein B-100.

Yu RZ, Lemonidis KM, Graham MJ, Matson J, Crooke RM, Tribble D, Wedel M, Levin AA, Geary RS.

Biochem Pharmacol. 2009 Mar 1;77(5):910-9. Epub 2008 Nov 14.

Lack of Pharmacokinetic Interaction of Mipomersen Sodium (ISIS 301012), a 2'-O-Methoxyethyl Modified Antisense Oligonucleotide Targeting Apolipoprotein B-100 Messenger RNA, with Simvastatin and Ezetimibe.

Yu RZ, Geary RS, Flaim JD, Riley GC, Tribble DL, vanVliet AA, Wedel MK.

Clinical Pharmacokinetics. 2009 January;48(1):39-50.

Antisense Oligonucleotide Directed to Human Apolipoprotein B-100 Reduces Lipoprotein(a) Levels and Oxidized Phospholipids on Human Apolipoprotein B-100 Particles in Lipoprotein(a) Transgenic Mice.

Merki E, Graham MJ, Mullick AE, Miller ER, Crooke RM, Pitas RE, Witztum JL, Tsimikas S.

Circulation. 2008 August;118:743-753.

Antisense Inhibition of Proprotein Convertase Subtilisin Kexin 9 Reduces Serum LDL in Hyperlipidemic Mice.

Graham MJ, Lemonidis KM, Whipple CP, Subramaniam A, Monia BP, Crooke ST, Crooke RM.

J Lipid Res. 2007 Jan 24

Aberrant Hepatic Expression of PPAR{gamma}2 Stimulates Hepatic Lipogenesis in a Mouse Model of Obesity, Insulin Resistance, Dyslipidemia, and Hepatic Steatosis.

Zhang YL, Hernandez-Ono A, Siri P, Weisberg S, Conlon D, Graham MJ, Crooke RM, Huang LS, Ginsberg HN.

J Biol Chem. 2006 Dec 8;281(49):37603-15

Potent reduction of apolipoprotein B and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein B.

Kastelein JJ, Wedel MK, Baker BF, Su J, Bradley JD, Yu RZ, Chuang E, Graham MJ, Crooke RM.

Circulation. 2006 Oct 17;114(16):1729-35.

Drug evaluation: ISIS-301012, an antisense oligonucleotide for the treatment of hypercholesterolemia.

Burnett JR.

Curr Opin Mol Ther. 2006 Oct;8(5):461-7.

Liver-specific inhibition of acyl-coenzyme a:cholesterol acyltransferase 2 with antisense oligonucleotides limits atherosclerosis development in apolipoprotein B100-only low-density lipoprotein receptor-/- mice.

Bell TA 3rd, Brown JM, Graham MJ, Lemonidis KM, Crooke RM, Rudel LL.

Arterioscler Thromb Vasc Biol. 2006 Aug;26(8):1814-20.

An Apolipoprotein B Antisense Oligonucleotide Lowers LDL Cholesterol in Hyperlipidemic Mice without Causing Hepatic Steatosis.

Crooke RM, Graham MJ, Lemonidis KM, Whipple CP, Koo S, Perera RJ.

J Lipid Res. 2005 May;46(5):872-84

Characterization of a Potent and Specific Class of Antisense Oligonucleotide Inhibitor of Human Protein Kinase C-alpha Expression.

McKay RA, Miraglia LJ, Cummins LL, Owens SR, Sasmor H, Dean NM.

J Biol Chem. 1999 Jan;274(3):1715-22