Metabolic

Inhibition of Protein Tyrosine Phosphatase-1B (PTP-1B) with Antisense Oligonucleotides Improves Insulin Sensitivity and Increases Adiponectin Concentrations in Monkeys.

Swarbrick MM, Havel PJ, Levin AA, Bremer AA, Stanhope KL, Butler M, Booten SL, Graham JL, McKay RA, Murray SF, Watts LM, Monia BP, Bhanot S.

Endocrinology. 2009 April;150(4):1670-9.

The Role of Peroxisome Proliferator-Activated Receptor gamma Coactivator-1 beta in the Pathogenesis of Fructose-Induced Insulin Resistance.

Nagai Y, Yonemitsu S, Erion DM, Iwasaki T, Stark R, Weismann D, Dong J, Zhang D, Jurczak MJ, Loeffler MG, Cresswell J, Yu XX, Murray SF, Bhanot S, Monia BP, Bogan JS, Samuel V, Shulman GI.

Cell Metab. 2009 March;9(3):252-64.

TNF-alpha Plays a Role in Hepatocyte Apoptosis in Niemann Pick Type C Liver Disease.

Rimkunas VM, Graham MJ, Crooke RM, Liscum L.

J Lipid Res. 2009 Feb;50(2):327-33

PKCepsilon Plays a Causal Role in Acute Ethanol-induced Steatosis.

Kaiser JP, Beier JI, Zhang J, David Hoetker J, von Montfort C, Guo L, Zheng Y, Monia BP, Bhatnagar A, Arteel GE.

Arch Biochem Biophys . 2009 February;482(1-2):104-11.

Differential Effects of JNK1 and JNK2 Inhibition on Murine Steatohepatitis and Isulin Resistance.

Singh R, Wang Y, Xiang Y, Tanaka KE, Gaarde WA, Czaja MJ.

Hepatology. 2009 January;49:87-96.

Altered Hepatic Triglyceride Content after Partial Hepatectomy without Impaired Liver Regeneration in Multiple Genetic Models.

Newberry EP, Kennedy SM, Xie Y, Luo J, Stanley SE, Semenkovich CF, Crooke RM, Graham MJ, Davidson NO.

Hepatology. 2008 Oct;48(4):1097-105.

Inhibition of ADRP Prevents Diet-induced Insulin Resistance.

Varela GM, Antwi DA, Dhir R, Yin X, Singhal NS, Graham MJ, Crooke RM, Ahima RS.

Am J. Physiol Gastrointest Liver Physiol. 2008 Sep;295(3):G621-8.

GL12 Knockdown Using an Antisense Oligonucleotide Induces Apoptosis and Chemosensitizes Cells to Paclitaxel in Androgen-Independent Prostate Cancer.

Narita S, So A, Ettinger S, Hayashi N, Muramaki M, Fazli L, Kim Y, Gleave M.

Clinical Cancer Res. 2008 September;14:5769-5777.

Reduction of JNK1 Expression with Antisense Oligonucleotide Improves Adiposity in Obese Mice.

Yu XX, Murray SF, Watts L, Booten SL, Tokorcheck J, Monia BP, Bhanot S.

Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E436-45.

Reduced Adiposity and Improved Insulin Sensitivity in Obese Mice with Antisense Suppression of 4E-BP2 Expression.

Yu XX, Pandey SK, Booten SL, Murray SF, Monia BP, Bhanot S.

Am J Physiol Endocrinol Metab. 2008 Mar;294(3):E530-9.

Diacylglycerol acyltransferase 1 anti-sense oligonucleotides reduce hepatic fibrosis in mice with nonalcoholic steatohepatitis.

Yamaguchi K, Yang L, McCall S, Huang J, Yu XX, Pandey SK, Bhanot S, Monia BP, Li YX, Diehl AM.

Hepatology. 2008 February;47(2):625-635.

Specific Down-regulation of Connective Tissue Growth Factor Attenuates Progression of Nephropathy in Mouse Models of Type 1 and Type 2 Diabetes.

Guha M, Xu ZG, Tung D, Lanting L, Natarajan R.

FASEB J. 2007 Oct;21(12):3355-68.

Inhibiting Triglyceride Synthesis Improves Hepatic Steatosis but Exacerbates Liver Damage and Fibrosis in Obese Mice with Nonalcoholic Steatohepatitis.

Yamaguchi K, Yang L, McCall S, Huang J, Yu XX, Pandey SK, Bhanot S, Monia BP, Li YX, Diehl AM.

Hepatalogy. 2007 Jun;45(6):1366-74.

Specific Reduction of Hepatic Glucose 6-phospate Transporter-1 Ameliorates Diabetes While Avoiding Complications of Glycogen Storage Disease.

Sloop KW, Showalter AD, Cox AL, Cao JX, Siesky AM ,Zhang HY, Irizarry AR,Murray SF, Booten SL, Finger EA, McKay RA, Monia BP, Bhanot S, Michael MD.

J Biol Chem. 2007 Jun 29;282(26):19113-21.

Reduction of Low-Molecular-Weight Protein Tyrosine Phosphatase Expression Improves Hyperglycemia and Insulin Sensitivity in Obese Mice.

Pandey SK, Yu XX, Watts LM, Michael MD, Sloop KW, RIvard AR, Leedon TA, Manchem VP, Samadzadeh L, McKay RA, Monia BP, Bhanot S.

J Bio Chem. 2007 Mar 12; [Epub ahead of print].

Inhibition of Protein Kinase Cepsilon Prevents Hepatic Insulin Resistance in Nonalcoholic Fatty Liver Disease.

Samuel VT, Liu ZX, Wang A, Beddow SA, Geisler JG, Kahn M, Zhang XM, Monia BP, Bhanot S, Shulman GI.

J Clin Invest. 2007 Mar;117(3):739-45.

Targeting foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action.

Samuel VT, Choi CS, Phillips TG, Romanelli AJ, Geisler JG, Bhanot S, McKay R, Monia B, Shutter JR, Lindberg RA, Shulman GI, Veniant MM.

Diabetes. 2006 Jul;55(7):2042-50.

Reversal of Diet-induced Hepatic Steatosis and Hepatic Insulin Resistance by Antisense Oligonucleotide Inhibitors of Acetyl-CoA Carboxylases 1 and 2.

Savage DB, Choi CS, Samuel VT, Liu ZX, Zhang D, Wang A, Zhang XM, Cline GW, Yu XX, Geisler JG, Bhanot S, Monia BP, Shulman GI.

J Clin Invest. 2006 Mar;116(3):817-24.

miR-122 Regulation of Lipid Metabolism Revealed by in vivo Antisense Targeting.

Esau C, Davis S, Murray SF, Yu XX, Pandey SK, Pear M, Watts L, Booten SL, Graham M, McKay R, Subramaniam A, Propp S, Lollo BA, Freier S, Bennett CF, Bhanot S, Monia BP.

Cell Metab. 2006 Feb;3(2):87-98.

Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice.

Yu XX, Murray SF, Pandey SK, Booten SL, Bao D, Song XZ, Kelly S, Chen S, McKay R, Monia BP, Bhanot S.

Hepatology. 2005 Aug;42(2):362-71.

Reduction of Hepatic and Adipose Tissue Glucocorticoid Receptor Expression with Antisense Oligonucleotides Improves Hyperglycemia and Hyperlipidemia in Diabetic Rodents without Causing Systemic Glucocorticoid Antagonism.

Watts LM, Manchem VP, Leedom TA, Rivard AL, McKay RA, Boa D, Neroladakis T, Monia BP, Bodenmiller DM, Cao JX, Zhang HY, Cox AL, Jacobs SJ, Michael MD, Sloop KW, Bhanot S.

Diabetes. 2005 Jun;54(6):1846-53.

Severe Impairment in Liver Insulin Signaling Fails to Alter Hepatic Insulin Action in Conscious Mice.

Buettner C, Patel R, Muse ED, Bhanot S. Monia BP, McKay R, Obici S, Rossetti L.

J Clin Invest. 2005 May;115(5):1306-13.

Reduction in Glucagon Receptor Expression by an Antisense Oligonucleotide Ameliorates Diabetic Syndrome in db/db mice.

Liang Y, Osborne MC, Monia BP, Bhanot S, Gaarde WA, Reed C, She P, Jetton TL, Demarest KT.

Diabetes. 2004 Feb;53(2):410-7.

Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis.

Rondinone, C.M., Trevillyan, J.M., Clampit, J., Gum, R.J., Berg, C., Kroeger, P., Frost, L., Zinker, B.A., Reilly, R., Ulrich, R., Butler, M., Monia, B.P., Jirousek, M.R., and Waring, J.F.

Diabetes. 2002 Aug;51(8):2405-11.

Specific inhibition of PTEN expression reverses hyperglycemia in diabetic mice.

Butler, M., McKay, R.A., Popoff, I.J., Gaarde, W.A., Witchell, D., Murray, S.F., Dean, N.M., Bhanot, S., and Monia, B.P.

Diabetes. 51(4):1028-34, 2002.

PTP1B antisense oligonucleotides lowers PTP1B protein, normalizes blood glucose, and improved insulin sensitivity in diabetic mice.

Zinker, B.A., Rondinone, C.M., Trevillyan, J.M., Gum, R.J., Clampit, J.E., Waring, J.F., Xie, N., Wilcox, D., Jacobson, P., Frost, L., Kroeger, P.E., Reilly, R.M., Koterski, S., Opgenorth, T.J., Ulrich, R.G., Crosby, S., Butler, M., Murray, S.F., McKay, R

Proc. Natl. Acad. Sci. USA 99 (17): 11357-11362, 2002.

Reduction of liver fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis

Zhang, H., Cook, J., Nickel, J., Yu, R., Stecker, K., Myers, K., and Dean, N. M.

Nat Biotechnol. 18(8):862-867, 2000.