Cancer

Expression of ARC (Apoptosis Repressor with Caspase Recruitment Domain), an Antiapoptotic Protein, is Strongly Prognostic in AML

Carter BZ, Qiu YH, Zhang N, Coombes KR, Mak DH, Thomas DA, Ravandi F, Kantarjian HM, Koller E, Andreeff M, Kornblau SM

Blood. 2011 Jan 20;117(3):780-7

hsa-miR-191 Is a Candidate Oncogene Target for Hepatocellular Carcinoma Therapy

Elyakim E, Sitbon E, Faerman A, Tabak S, Montia E, Belanis L, Dov A, Marcusson EG, Bennett CF, Chajut A, Cohen D, Yerushalmi N

Cancer Res. 2010 Oct 15;70(20):8077-87

Matrix Metalloproteinase (MMP)-13 Regulates Mammary Tumor-Induced Osteolysis by Activating MMP9 and Transforming Growth Factor-{beta} Signaling at the Tumor-Bone Interface

Nannuru KC, Futakuchi M, Varney ML, Vincent TM, Marcusson EG, Singh RK

Cancer Res. 2010 May 1;70(9):3494-504

Antisense Oligonucleotide Targeting of Insulin-Like Growth Factor-1 Receptor (IGF-1R) in Prostate Cancer

Furukawa J, Wraight CJ, Freier SM, Peralta E, Atley LM, Monia BP, Gleave ME, Cox ME

Prostate. 2010 Feb 1;70(2):206-18

Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML

Carter BZ, Mak DH, Schober WD, Koller E, Pinilla C, Vassilev LT, Reed JC, Andreeff M

Blood. 2010 Jan 14;115(2):306-14

Enhanced Expression and Shedding of Receptor Activator of NF-kappaB Ligand During Tumor-bone Interaction Potentiates Mammary Tumor-induced Osteolysis

Nannuru KC, Futakuchi M, Sadanandam A, Wilson TJ, Varney ML, Myers KJ, Li X, Marcusson EG, Singh RK

Clin Exp Metastasis. 2009 Jul 10;26(7):797-808

Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase.

Bulavin, D.V., Higashimoto, Y., Popoff, I.J., Gaarde, W.A., Basrur, V., Potapova, O. Appella, E., and Fornace, Jr., A.J.

Nature. 2001 May 3;411(6833):102-7.

GLl2 Knockdown Using an Antisense Oligonucleotide Induces Apoptosis and Chemosensitizes Cells to Paclitaxel in Androgen-independent Prostate Cancer.

Narita S, So A, Ettinger S, Hayashi N, Muramaki M, Fazli L, Kim Y, Gleave ME.

Clin Cancer Res. 2008 Sep 15;14(18):5769-77.

STAT3 and STAT1 Mediate IL-11-Dependent and Inflammation-Associated Gastric Tumorigenesis in gp130 Receptor Mutant Mice

Ernst M, Najdovska M, Grail D, Lundgren-May T, Buchert M, Tye H, Matthews VB, Armes J, Bhathal PS, Hughes NR, Marcusson EG, Karras JG, Na S, Sedgwick JD, Hertzog PJ, Jenkins BJ

J Clin Invest. 2008 May;118(5):1727-38

Targeting the Eukaryotic Translation Initiation Factor 4E for Cancer Therapy.

Graff JR, Konicek BW, Konicek W, Carter JH, Marcusson EG.

Cancer Res. 2008 February;68(3):631-634

Therapeutic Suppression of Translation Initiation Factor eIF4E Expression Reduces Tumor Growth Without Toxicity.

Graff JR, Konicek BW, Vincent TM, Lynch RL, Monteith D, Weir SN, Schwier P, Capen A, Goode RL, Dowles MS, Chen Y, Zhang H, Sissons S, Cox K, McNulty AN, Parsons SH, Wang T, Sams L, Geeganage S, Douglass LE, Neubauer BL, Dean NM, Blanchard K, Shou J, Stanc

J Clin Invest. 2007 September;117:2638-2648.

P53-independent NOXA Induction Overcomes Apoptotic Resistance of Malignant Melanomas.

Qin JZ, Stennett L, Bacon P, Bodner B, Hendrix MJ, Seftor RE, Seftor EA, Margaryan NV, Pollock PM, Curtis A, Trent JM, Bennett F, Miele L. Nickoloff BJ

Mol Cancer Ther. 2004 Aug;3(8):895-902

Autocrine Prolactin Promotes Prostate Cancer Cell Growth via Jak2-Stat5a/b Signaling Pathway.

Dagvadorj A, Collins S, Jomain JB, Abdulghani J, Karras J, Zellweger T, Li H, Nurmi M, Alanen K, Mirtti T, Visakorpi T., Budendorf L, Goffin V, Nevalainen MT.

Endocrinology. 2007 Apr 5; [Epub ahead of print].

Selective Down-regulation of Glioma-associated Oncogene 2 Inhibits the Proliferation of Hepatocellular Carcinoma Cells.

Kim Y, Yoon JW, Xiao X, Dean NM, Monia BP, Marcusson EG.

Cancer Res. 2007 Apr 15;67(8):3583-93.

A phase I pharmacokinetic and pharmacodynamic study of OGX-011, a 2'-methoxyethyl antisense oligonucleotide to clusterin, in patients with localized prostate cancer.

Chi KN, Eisenhauer E, Fazli L, Jones EC, Goldenberg SL, Powers J, Tu D, Gleave ME.

J Natl Cancer Inst. 2005 Sep 7;97(17):1287-96.

Antitumor activity of antisense clusterin oligonucleotides is improved in vitro and in vivo by incorporation of 2'-o-(2-methoxyethyl).

Zellweger, T., Miyake, H., Cooper, S., Chi, K., Conklin, B.S., Monia, B.P., and Gleave, M.E.

J Pharmacol Exp Ther. 298(3): 934-940, 2001.

Pleiotropic cell-division defects and apoptosis induced by interference with survivin function.

Li, F., Ackermann, E.J., Bennett, C.F., Rothermel, A.L., Plescia, J., Tognin, S., Villa, A., Marchisio, P.C., and Altieri, D.C.

Nature Cell Biol. 1:461-466, 1999.