Cancer

Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase.

Bulavin, D.V., Higashimoto, Y., Popoff, I.J., Gaarde, W.A., Basrur, V., Potapova, O. Appella, E., and Fornace, Jr., A.J.

Nature. 2001 May 3;411(6833):102-7.

GL!2 Knockdown Using an Antisense Oligonucleotide Induces Apoptosis and Chemosensitizes Cells to Paclitaxel in Androgen-independent Prostate Cancer.

Narita S, So A, Ettinger S, Hayashi N, Muramaki M, Fazli L, Kim Y, Gleave ME.

Clin Cancer Res. 2008 Sep 15;14(18):5769-77.

Translational Regulation of Lipoprotein Lipase in Adipocytes: Depletion of Cellular Protein Kinase Calpha Activates Binding of the C Subunit of Protein Kinase A to the 3'-untranslated Region of the Lipoprotein Lipase mRNA.

Unal R, Pokrovskaya I, Tripathi P, Monia BP, Kern PA, Ranganathan G.

Biochem J. 2008 July;413(2):315-22.

Translational Regulation of Lipoprotein Lipase in Adipocytes: Depletion of Cellular Protein Kinase Calpha Activates Binding of the C Subunit of Protein Kinase A to the 3'-untranslated Region of the Lipoprotein Lipase mRNA.

Unal R, Pokrovskaya I, Tripathi P, Monia BP, Kern PA, Ranganathan G.

Biochem J. 2008 July;413(2):315-22.

Regulation of H(2)O(2)-induced Necrosis by PKC and AMP-activated Kinase Signaling in Primary Cultured Hepatocytes.

Saberi B, Shinohara M, Ybanez MD, Hanawa N, Gaarde WA, Kaplowitz N, Han D.

Am J Physiol Cell Physiol. 2008 July;295(1):C50-63.

Targeting the Eukaryotic Translation Initiation Factor 4E for Cancer Therapy.

Graff JR, Konicek BW, Konicek W, Carter JH, Marcusson EG.

Cancer Res. 2008 February;68(3):631-634

Therapeutic Suppression of Translation Initiation Factor eIF4E Expression Reduces Tumor Growth Without Toxicity.

Graff JR, Konicek BW, Vincent TM, Lynch RL, Monteith D, Weir SN, Schwier P, Capen A, Goode RL, Dowles MS, Chen Y, Zhang H, Sissons S, Cox K, McNulty AN, Parsons SH, Wang T, Sams L, Geeganage S, Douglass LE, Neubauer BL, Dean NM, Blanchard K, Shou J, Stanc

J Clin Invest. 2007 September;117:2638-2648.

P53-independent NOXA Induction Overcomes Apoptotic Resistance of Malignant Melanomas.

Qin JZ, Stennett L, Bacon P, Bodner B, Hendrix MJ, Seftor RE, Seftor EA, Margaryan NV, Pollock PM, Curtis A, Trent JM, Bennett F, Miele L. Nickoloff BJ

P53-independent NOXA Induction Overcomes Apoptotic Resistance of Malignant Melanomas.

Autocrine Prolactin Promotes Prostate Cancer Cell Growth via Jak2-Stat5a/b Signaling Pathway.

Dagvadorj A, Collins S, Jomain JB, Abdulghani J, Karras J, Zellweger T, Li H, Nurmi M, Alanen K, Mirtti T, Visakorpi T., Budendorf L, Goffin V, Nevalainen MT.

Endocrinology. 2007 Apr 5; [Epub ahead of print].

Selective Down-regulation of Glioma-associated Oncogene 2 Inhibits the Proliferation of Hepatocellular Carcinoma Cells.

Kim Y, Yoon JW, Xiao X, Dean NM, Monia BP, Marcusson EG.

Cancer Res. 2007 Apr 15;67(8):3583-93.

Use of a Chemically Modified Antisense Oligonucleotide Library to Identify and Validate Eg5 (Kinesin-like 1) as a Target for Antineoplastic Drug Development.

Koller E, Propp S, Zhang H, Zhao C, Xiao X, Chang M, Hirsch SA, Shepard PJ, Koo S, Murphy C, Glazer RI, Dean NM.

Cancer Res. 2006 Feb 15;66(4):2059-66.

Effect of Focal Adhesion Kinase (FAK) Downregulation with FAK Antisense Oligonucleotides and 5-fluorouracil on the Viability of Melanoma Cell Lines.

Smith CS, Golubovskaya VM, Peck E, Xu LH, Monia BP, Yang X, Cance WG.

Melanoma Res. 2005 Oct;15(5):357-62.

A phase I pharmacokinetic and pharmacodynamic study of OGX-011, a 2'-methoxyethyl antisense oligonucleotide to clusterin, in patients with localized prostate cancer.

Chi KN, Eisenhauer E, Fazli L, Jones EC, Goldenberg SL, Powers J, Tu D, Gleave ME.

J Natl Cancer Inst. 2005 Sep 7;97(17):1287-96.

Proteasome Inhibitors Trigger NOXA-mediated Apoptosis in Melanoma and Myeloma Cells.

Qin JZ, Ziffra J, Stennett L, Bodner B, Bonish BK, Chaturvedi V, Bennett F, Pollock PM, Trent JM, Hendrix MJ, Rizzo P, Miele L, Nickoloff BJ.

Cancer Res. 2005 Jul;65(14):6282-93.

Mcl-1 is Required for Akata6 B-lymphoma Cell Survival and is Converted to a Cell Death Molecule by Efficient Caspase-mediated Cleavage.

Michels J, O’Neill JW, Dallman CL, Mouzakiti A, Habens F, Brimmell M, Zhang KY, Craig RW, Marcusson EG, Johnson PW, Packham G.

Oncogene. 2004 Jun 17;23(28):4818-27.

Mcl-1 Antisense Therapy Chemosensitizes Human Melanoma in SCID Mouse Xenotransplantation Model.

Thallinger C, Wolschek MF, Wacheck V, Maierhofer H, Guensberg P, Polterauer P, Pehamberger H, Monia BP, Selzer E, Wolff K, Jansen B.

J Invest dermatol. 2003 Jun;120(6):1081-6.

C-Jun NH(2)-terminal Kinase Mediates Proliferation and Tumor Growth of Human Prostate Carcinoma.

Yang YM, Bost F, Charbono W, Dean N, McKay R, Rhim JS, Depatie C, Mercola D.

Clin Cancer Res. 2003 Jan;9(1):391-401.

Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1.

Pedersen, I.M., Kitada, S., Leoni, L.M., Zapata, J.M., Karras, J.G., Tsukada, N., Kipps, T.J., Choi, Y.S., Bennett, F., Reed, J.C.

Blood. 2002 Sep 1;100(5):1795-801.

In Vivo Expression of bcl-xl expression facilitates chemotherapy-induced leukemia cell death in a scid/nod-hu model

Fennell, D.A., Corbo, M.V., Dean, N.M., Monia, B.P., and Cotter, F.E.

Br J Haematol. 112(3): 706-713, 2001.

Suppression of vascular endothelial growth factor-mediated endothelial cell protection by survivin targeting.

Mesri, M., Morales-Ruiz, M., Ackermann, E. J., Bennett, C. F., Pober, J. S., Sessa, W. C., and Altieri, D. C.

Am J Pathol. 158(5):1757-1765, 2001.

Antitumor activity of antisense clusterin oligonucleotides is improved in vitro and in vivo by incorporation of 2'-o-(2-methoxyethyl).

Zellweger, T., Miyake, H., Cooper, S., Chi, K., Conklin, B.S., Monia, B.P., and Gleave, M.E.

J Pharmacol Exp Ther. 298(3): 934-940, 2001.

Pleiotropic cell-division defects and apoptosis induced by interference with survivin function.

Li, F., Ackermann, E.J., Bennett, C.F., Rothermel, A.L., Plescia, J., Tognin, S., Villa, A., Marchisio, P.C., and Altieri, D.C.

Nature Cell Biol. 1:461-466, 1999.