Neurodegenerative

Spinal Distribution and Metabolism of 2’-O-(2-methoxyethyl)-modified Oligonucleotides after Intrathecal Administration in Rats.

Butler M, Hayes CS, Chappell A, Murray SF, Yaksh TL, Hua XY.

Neuroscience. 2005;131(3):705-15.

Inhibition of Spinal Cytosolic Phospholipase A(2) Expression by an Antisense Oligonucleotide Attenuates Tissue Injury-induced Hyperalgesia.

Kim DH, Fitzsimmons B, Hefferan MP, Svensson CI, Wancewicz E, Monia BP, Hung G, Butler M, Marsala M, Hua XY, Yaksh TL .

Neuroscience. 2008 Jun 26;154(3):1077-87.

Enhancement of SMN2 Exon 7 Inclusion by Antisense Oligonucleotides Targeting the Exon.

Hua Y, Vickers TA, Baker BF, Bennett CF, Krainer AR.

PLOS Biol. 2007 April;5(4):e73.

Antisense oligonucleotide therapy for neurodegenerative disease.

Smith RA, Miller TM, Yamanaka K, Monia BP, Condon TP, Hung G, Lobsiger CS, Ward CM, McAlonis-Downes M, Wei H, Wancewicz EV, Bennett CF, Cleveland DW.

J Clin Invest. 2006 Aug;116(8):2290-6. Epub 2006 Jul 27.