Other Therapeutic Areas

Measuring Antiviral Activity of Benzimidazole Molecules That Alter IRES RNA Structure With an Infectious Hepatitis C Virus Chimera Expressing Renilla Luciferase

Liu S, Nelson CA, Xiao L, Lu L, Seth PP, Davis DR, Hagedorn CH

Antiviral Res. 2011 Jan;89(1):54-63

Activating the Synthesis of Progerin, the Mutant Prelamin A in Hutchinson-Gilford Progeria Syndrome, with Antisense Oligonucleotides

Fong LG, Vickers TA, Farber EA, Choi C, Yun UJ, Hu Y, Yang SH, Coffinier C, Lee R, Yin L, Davies BS, Andres DA, Spielmann HP, Bennett CF, Young SG.

Hum Mol Genet . 2009 July;18(13):2462-71.

Amphoteric Liposomes Enable Systemic Antigen-Presenting Cell-Directed Delivery of CD40 Antisense and are Therapeutically Effective in Experimental Arthritis.

Andreakos E, Rauchhaus U, Stavropoulos A, Endert G, Wendisch V, Benahmed AS, Giaglis S, Karras J, Lee S, Gaus H, Bennett CF, Williams RO, Sideras P, Panzner S.

Arthritis Rheum. 2009 March;60(4):994-1005.

TNF-alpha Plays a Role in Hepatocyte Apoptosis in Niemann Pick Type C Liver Disease.

Rimkunas VM, Graham MJ, Crooke RM, Liscum L.

J Lipid Res. 2008 September [Epub ahead of print].

Inhaled CD86 Antisense Oligonucleotide Suppresses Pulmonary Inflammation and Airway Hyper-responsiveness in Allergic Mice.

Crosby JR, Guha M, Tung D, Miller DA, Bender B, Condon TP, York-DeFalco C, Geary RS, Monia BP, Karras JG, Gregory SA

J Pharmacol Exp Ther. 2007 Jun;321(3):938-46

Inhaled p38alpha Mitogen-activated Protein Kinase Antisense Oligonucleotide Attenuates Asthma in Mice.

Duan W, Chan JH, McKay K, Crosby JR, Choo HH, Leung BP, Karras JG, Wong WS.

Am J Respir Crit Care Med. 2005 Mar 15;171(6):571-8.

Antisense oligonucleotide blockade of tumor necrosis factor-alpha in two murine models of colitis.

Myers, K.J., Murthy, S., Flanigan, A., Witchell, D.R., Butler, M., Murray, S., Siwkowski, A., Goodfellow, D., Madsen, K., Baker, B.

J Pharmacol Exp Ther. 304(1):411-424, 2003.

Intravitreous anti-raf-1 kinase antisense oligonucleotide as an angioinhibitory agent in porcine preretinal neovascularization.

Danis R, Criswell M, Orge F, Wancewicz E, Stecker K, Henry S, Monia B.

Curr Eye Res. 2003 Jan;26(1):45-54

Amelioration of chronic and spontaneous intestinal inflammation with an antisense oligonucleotide (ISIS 9125) to ICAM-1 in the HLA-B27/2 microglobulin transgenic rat model.

Bowen-Yacyshyn, M.B., Bennett, C.F., Nation, N., Raynor, D., and Yacyshyn, B.R.

J Pharmacol Exp Ther. 2002 Sep;302(3):908-17.

Potential therapeutic application of antisense oligonucleotides in the treatment of ocular diseases.

Danis RP, Henry SP, Ciulla TA.

Expert Opin Pharmacother. 2001 Feb;2(2):277-91

Inhibition of human cytomegalovirus replication in human retinal epitheal cell model by antisense oligonucleotide.

Detrick, B., Nagineni, C.N., Grillone, L.R., Anderson, K.P., Henry, S.P., and Hooks, J.J.

Invest Ophthalmol Vis Sci. 2001 Jan;42(1):163-9.

Inhibition of antigen-induced eosinophilia and late phase airway hyperresponsiveness by an Il-5 antisense oligonucleotide in mouse models of asthma.

Karras, J. G., McGraw, K., McKay, R. A., Cooper, S. R., Lerner, D., Lu, T., Walker, C., Dean, N. M., and Monia, B. P.

J Immunol. 164(10):5409-5415, 2000.

Antisense oligonucleotide inhibition of hepatitis c virus (hcv) gene expression in livers of mice infected with an hcv-vaccinia virus recombinant.

Zhang, H., Hanecak, R., Brown-Driver, V., Azad, R., Conklin, B., Fox, M. C., and Anderson, K. P.

Antimicrobial Agents and Chemotherapy. 43(2):347-353, 1999.

An icam-1 antisense oligonucleotide prevents and reverses dextran sulfate sodium-induced colitis in mice.

Bennett, C. F., Kornbrust, D., Henry, S., Stecker, K., Howard, R., Cooper, S., Dutson, S., Hall, W., and Jacoby, H. I

J Pharmacol Exp Ther. 280(2):988-1000, 1997.

Antisense oligonucleotide inhibition of hepatitis c virus gene expression in transformed hepatocytes.

Hanecak, R., Brown-Driver, V., Fox, M.C., Azad, R.F., Furusako, S. Nozaki, C., Ford, C., Sasmor, H., Anderson, K.P.

Journal of Virology. 70(8):5203-5212, 1996.